Article
BMP-6 over-expression in prostate cancer is associated with increased Id-1 protein and a more invasive phenotype.
The Journal of pathology - 1 Feb 2008
Darby S, Cross S S, Brown N J, Hamdy F C, Robson C N
Abstract excerpt
Bone morphogenetic protein-6 (BMP-6) has been strongly implicated in prostate cancer development and bone metastasis. Our previous data showed that BMP-6 mRNA was absent in patients with benign prostatic hyperplasia, but evident in primary tumours with established secondary skeletal metastases. To examine the role of BMP-6 in prostate cancer progression, we have developed a BMP-6-regulatable,...
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