Article
Identification of the first synthetic steroidogenic factor 1 inverse agonists: pharmacological modulation of steroidogenic enzymes.
Molecular pharmacology - 1 Mar 2008
Del Tredici Andria L, Andersen Carsten B, Currier Erika A, Ohrmund Steven R, Fairbain Luke C, Lund Birgitte W, Nash Norman, Olsson Roger, Piu Fabrice
Abstract excerpt
Steroidogenic factor SF-1, a constitutively active nuclear hormone receptor, is essential to the development of adrenal and gonadal glands and acts as a shaping factor of sexual determination and differentiation. Its effects are exerted primarily through the control of the synthesis of steroid hormones. The functional cell-based assay Receptor Selection and Amplification Technology (R-SAT) was used to identify...
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