Article
VPS9a, the common activator for two distinct types of Rab5 GTPases, is essential for the development of Arabidopsis thaliana.
The Plant cell - 1 Nov 2007
Goh Tatsuaki, Uchida Wakana, Arakawa Satoko, Ito Emi, Dainobu Tomoko, Ebine Kazuo, Takeuchi Masaki, Sato Ken, Ueda Takashi, Nakano Akihiko
Abstract excerpt
Rab5, a subfamily of Rab GTPases, regulates a variety of endosomal functions as a molecular switch. Arabidopsis thaliana has two different types of Rab5-member GTPases: conventional type, ARA7 and RHA1, and a plant-specific type, ARA6. We found that only one guanine nucleotide exchange factor (GEF), named VPS9a, can activate all Rab5 members to GTP-bound forms in vitro in spite of their diverged structures. In...
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