Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nociceptive tuning by stem cell factor/c-Kit signaling.

Neuron - 6 Dec 2007

Milenkovic Nevena, Frahm Christina, Gassmann Max, Griffel Carola, Erdmann Bettina, Birchmeier Carmen, Lewin Gary R, Garratt Alistair N

Abstract excerpt

The molecular mechanisms regulating the sensitivity of sensory circuits to environmental stimuli are poorly understood. We demonstrate here a central role for stem cell factor (SCF) and its receptor, c-Kit, in tuning the responsiveness of sensory neurons to natural stimuli. Mice lacking SCF/c-Kit signaling displayed profound thermal hypoalgesia, attributable to a marked elevation in the thermal threshold and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capsaicin
Share to Ganglia, Spinal
Share to Hyperalgesia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mechanoreceptors

Share to Neurons, Afferent

Share to Nociceptors

Share to Stem Cell Factor

Share to TRPV Cation Channels

Source

Identifiers

PMID: 18054864
DOI: 10.1016/j.neuron.2007.10.040

Genes

TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nociceptive tuning by stem cell factor/c-Kit signaling.PMID 18054864Read ↗

Essential role of Ret for defining non-peptidergic nociceptor phenotypes and functions in the adult mouse.Semantic proximity Read ↗

Signaling by sensory receptors.Semantic proximity Read ↗

The cellular code for mammalian thermosensation.Semantic proximity Read ↗

Mouse behavioral genomics identifies Creld1 as a gatekeeper of somatosensationSemantic proximity Read ↗

HESC-derived sensory neurons reveal an unexpected role for PIEZO2 in nociceptor mechanotransductionSemantic proximity Read ↗

Essential role of stem cell factor signaling in primary sensory neuron development.Semantic proximity Read ↗

Rapid peripheral reprogramming of myelinated afferents drives human hyperalgesiaSemantic proximity Read ↗

Nociceptors--noxious stimulus detectors.Semantic proximity Read ↗

TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception.Semantic proximity Read ↗

Identification of a Sacral, Visceral Sensory Transcriptome in Embryonic and Adult MiceSemantic proximity Read ↗

The transcription factor Cux2 marks development of an A-delta sublineage of TrkA sensory neurons.Semantic proximity Read ↗

Touch sensation requires the mechanically-gated ion channel Elkin1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.