Article
A strong exonic splicing enhancer in dystrophin exon 19 achieve proper splicing without an upstream polypyrimidine tract.
Journal of biochemistry - 1 Mar 2008
Habara Yasuaki, Doshita Mari, Hirozawa Sadako, Yokono Yuka, Yagi Mariko, Takeshima Yasuhiro, Matsuo Masafumi
Abstract excerpt
Proper splicing is known to proceed under the control of conserved cis-elements located at exon-intron boundaries. Recently, it was shown that additional elements, such as exonic splicing enhancers (ESEs), are essential for the proper splicing of certain exons, in addition to the splice donor and acceptor site sequences; however, the relationship between these cis-elements is still unclear. In this report, we...
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