Article
Decline of lactase activity and c/t-13910 variant in Sardinian childhood.
Journal of pediatric gastroenterology and nutrition - 1 Oct 2007
Schirru Enrico, Corona Valeria, Usai-Satta Paolo, Scarpa Maria, Cucca Francesco, De Virgiliis Stefano, Rossino Rossano, Frau Fulvia, Macis Maria Doloretta, Jores Rita-Désirée, Congia Mauro
Abstract excerpt
OBJECTIVES: Our study aims to determine the age of onset of adult-type hypolactasia in Sardinians, and to establish the age at which genotyping of the C/T-13910 variant can be used reliably in the diagnosis of lactose malabsorption. PATIENTS AND METHODS: A lactose breath hydrogen test was given to 383 randomly selected patients, from 3 to 19 years old. RESULTS: The C/C-13910 genotype was found in 90% of patients;...
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