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Role of insulin-like growth factor binding protein-4 in prevention of colon cancer

7 Nov 2007

Abstract excerpt

BACKGROUND: Insulin-like growth factors (IGFs) are important for the proliferation of cancer cells. One of their binding proteins, known as insulin-like growth factor binding protein -4 (IGFBP-4) is well known for its inhibitory action on IGFs in vitro. We assessed the effect of IGFBP-4 in prevention of development of colon cancer in vivo. METHODS: Nude mice were subcutaneously inoculated with HT-29 colon cancer...

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PMID: 17988381
DOI: 10.1186/1477-7819-5-128

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