Article
The Cables gene on chromosome 18q is silenced by promoter hypermethylation and allelic loss in human colorectal cancer.
The American journal of pathology - 1 Nov 2007
Park Do Youn, Sakamoto Hideo, Kirley Sandra D, Ogino Shuji, Kawasaki Takako, Kwon Eunjeong, Mino-Kenudson Mari, Lauwers Gregory Y, Chung Daniel C, Rueda Bo R, Zukerberg Lawrence R
Abstract excerpt
Cables is a cyclin-dependent kinase-binding nuclear protein that maps to chromosome 18q11-12. Here, we assessed Cables expression in 160 colorectal cancers (CRCs), its role in colon cancer cell growth, and the potential mechanisms of Cables inactivation. Expression levels, promoter methylation, and mutational status of Cables were investigated in colon cancer cell lines and primary colon tumors. Chromosome 18q...
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