Article
Ferroportin: lack of evidence for multimers.
Blood cells, molecules & diseases - 1 Jan 2000
Schimanski Lisa M, Drakesmith Hal, Talbott Charlotte, Horne Kerry, James John R, Davis Simon J, Sweetland Emma, Bastin Judy, Cowley Diana, Townsend Alain R M
Abstract excerpt
Ferroportin is a multi-transmembrane glycoprotein that mediates iron export from cells. Mutations in ferroportin are linked to type IV hemochromatosis, a dominantly inherited disorder of iron metabolism. Multimers of ferroportin, whose existence may relate to the dominant inheritance pattern of disease, have been detected in some studies but not others. We looked for evidence of multimerization in several...
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