Article
Identification of TyeA residues required to interact with YopN and to regulate Yop secretion.
Advances in experimental medicine and biology - 1 Jan 2007
Joseph Sabrina S, Plano Gregory V
Abstract excerpt
The secretion of Yops via the Yersinia type III secretion system (T3SS) is controlled, in part, by a cytoplasmic YopN/TyeA complex. This complex is required to prevent Yop secretion in the presence of extracellular calcium and prior to contact between the bacterium and a eukaryotic cell. In this study we utilized site-directed mutagenesis to analyze the role of specific TyeA regions and residues in the regulation...
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