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A novel method for generating and screening peptides and libraries displayed on adenovirus fiber

26 Oct 2007

Abstract excerpt

Capsid-displayed adenoviral peptide libraries have been a significant, yet unfeasible goal in biotechnology. Three barriers have made this difficult: the large size of the viral genome, the low efficiency of converting plasmid-based genomes into packaged adenovirus and the fact that library amplification is hampered by the ability of two (or more) virus to co-infect one cell. Here, we present a novel vector...

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Identifiers

PMID: 17965092
DOI: 10.1093/nar/gkm914

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