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Article

mRNA expression profiles of methylated APAF-1 and DAPK-1 tumor suppressor genes uncover clear cell renal cell carcinomas with aggressive phenotype.

The Journal of urology - 1 Dec 2007

Christoph F, Hinz S, Kempkensteffen C, Schostak M, Schrader M, Miller K

Abstract excerpt

PURPOSE: We determined the relation between promoter methylation and mRNA expression of the p53 target genes APAF-1 and DAPK-1 in 55 consecutive tumor and corresponding normal tissue samples. MATERIALS AND METHODS: Tissue was taken from nonmetastatic clear cell renal cell carcinoma at a median followup of 75 months. Quantitative methylation specific real-time polymerase chain reaction and quantitative real-time...

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Identifiers

PMID: 17945286
DOI: 10.1016/j.juro.2007.07.116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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