Article
Alternately spliced WT1 antisense transcripts interact with WT1 sense RNA and show epigenetic and splicing defects in cancer.
RNA (New York, N.Y.) - 1 Dec 2007
Dallosso Anthony R, Hancock Anne L, Malik Sally, Salpekar Ashreena, King-Underwood Linda, Pritchard-Jones Kathy, Peters Jo, Moorwood Kim, Ward Andrew, Malik Karim T A, Brown Keith W
Abstract excerpt
Many mammalian genes contain overlapping antisense RNAs, but the functions and mechanisms of action of these transcripts are mostly unknown. WT1 is a well-characterized developmental gene that is mutated in Wilms' tumor (WT) and acute myeloid leukaemia (AML) and has an antisense transcript (WT1-AS), which we have previously found to regulate WT1 protein levels. In this study, we show that WT1-AS is present in...
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