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Article

Essential Role of Chitinase in the Development of the Filarial Nematode Acanthocheilonema viteae

16 Oct 2007

Abstract excerpt

Chitinases of pathogens have been proposed as potential targets of vaccines or specific inhibitors. We studied the genomic organization, transcript levels, developmental expression, and biological function of chitinases in the rodent filarial nematode Acanthocheilonema viteae, a model organism for human-pathogenic filarial worms. Characterization of nine genomic clones from an A. viteae phage library and Southern...

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PMID: 17938220
DOI: 10.1128/iai.00701-07

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