Article
Lack of association between endoplasmic reticulum stress response genes and suicidal victims.
The Kobe journal of medical sciences - 1 Jan 2007
Sakurai Kaoru, Nishiguchi Naoki, Shirakawa Osamu, Nushida Hideyuki, Ueno Yasuhiro, Maeda Kiyoshi, Hayashi Yoshitake
Abstract excerpt
As lithium has been shown to have a protective effect against suicidal behavior, genes on which mood stabilizers act may be involved in biological susceptibility to suicide. A recent study showed that endoplasmic reticulum (ER) stress response was impaired in the bipolar disorders and the impairment was ameliorated by a mood stabilizer, valproate. We hypothesized that an alteration of ER stress response is...
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