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Article

Deletion of a 760 kb region at 4p16 determines the prenatal and postnatal growth retardation characteristic of Wolf-Hirschhorn syndrome.

Journal of medical genetics - 1 Oct 2007

Concolino Daniela, Rossi Elena, Strisciuglio Pietro, Iembo Maria Antonietta, Giorda Roberto, Ciccone Roberto, Tenconi Romano, Zuffardi Orsetta

Abstract excerpt

BACKGROUND: Recently the genotype/phenotype map of Wolf-Hirschhorn syndrome (WHS) has been refined, using small 4p deletions covering or flanking the critical region in patients showing only some of the WHS malformations. Accordingly, prenatal-onset growth retardation and failure to thrive have been found to result from haploinsufficiency for a 4p gene located between 0.4 and 1.3 Mb, whereas microcephaly results...

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Identifiers

PMID: 17911656
DOI: 10.1136/jmg.2007.050963
PMCID: PMC2597974

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Deletion of a 760 kb region at 4p16 determines the prenatal and postnatal growth retardation characteristic of Wolf-Hirschhorn syndrome.PMID 17911656Read ↗

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