Article
Assessment of algorithms for high throughput detection of genomic copy number variation in oligonucleotide microarray data.
BMC bioinformatics - 2 Oct 2007
Baross Agnes, Delaney Allen D, Li H Irene, Nayar Tarun, Flibotte Stephane, Qian Hong, Chan Susanna Y, Asano Jennifer, Ally Adrian, Cao Manqiu, Birch Patricia, Brown-John Mabel, Fernandes Nicole, Go Anne, Kennedy Giulia, Langlois Sylvie, Eydoux Patrice, Friedman J M, Marra Marco A
Abstract excerpt
BACKGROUND: Genomic deletions and duplications are important in the pathogenesis of diseases, such as cancer and mental retardation, and have recently been shown to occur frequently in unaffected individuals as polymorphisms. Affymetrix GeneChip whole genome sampling analysis (WGSA) combined with 100 K single nucleotide polymorphism (SNP) genotyping arrays is one of several microarray-based approaches that are...
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