Article
A novel variable number of tandem repeats (VNTR) polymorphism containing Sp1 binding elements in the promoter of XRCC5 is a risk factor for human bladder cancer.
Mutation research - 1 Feb 2008
Wang Shouyu, Wang Meilin, Yin Shiwei, Fu Guangbo, Li Chunping, Chen Rui, Li Aiping, Zhou Jianwei, Zhang Zhengdong, Liu Qizhan
Abstract excerpt
X-ray repair cross-complementing 5 (XRCC5) is a gene involved in repair of DNA double-strand breaks. Abnormal expression of the XRCC5 protein is associated with genomic instability and an increased incidence of cancers. In our study, a polymorphism with a variable number of tandem repeats (21-bp repeat elements at position -201 to -160 relative to the initiation of transcription) in the promoter of XRCC5 was...
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