Article
Computational genes: a tool for molecular diagnosis and therapy of aberrant mutational phenotype.
BMC bioinformatics - 28 Sept 2007
Martínez-Pérez Israel M, Zhang Gong, Ignatova Zoya, Zimmermann Karl-Heinz
Abstract excerpt
BACKGROUND: A finite state machine manipulating information-carrying DNA strands can be used to perform autonomous molecular-scale computations at the cellular level. RESULTS: We propose a new finite state machine able to detect and correct aberrant molecular phenotype given by mutated genetic transcripts. The aberrant mutations trigger a cascade reaction: specific molecular markers as input are released and...
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