Vaccination with a DNA vaccine based on human PSCA and HSP70 adjuvant enhances the antigen‐specific CD8⁺ T‐cell response and inhibits the PSCA⁺ tumors growth in mice

Abstract excerpt

BACKGROUND: DNA vaccines have been shown to be an effective approach to induce antigen-specific cellular and humoral immunity. However, the lower immune intensity in clinical trials limits the application of DNA vaccine. Here we intend to develop a new DNA vaccine based on prostate stem-cell antigen (PSCA), which has been suggested as a potential target for prostate cancer therapy, and enhance the DNA vaccine...

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