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Article

Haploinsufficiency of utrophin gene worsens skeletal muscle inflammation and fibrosis in mdx mice.

Journal of the neurological sciences - 15 Jan 2008

Zhou Lan, Rafael-Fortney Jill A, Huang Ping, Zhao Xinyu S, Cheng Georgiana, Zhou Xiaohua, Kaminski Henry J, Liu Liping, Ransohoff Richard M

Abstract excerpt

To address whether mdx mice with haploinsufficiency of utrophin (mdx/utrn+/-) develop more severe skeletal muscle inflammation and fibrosis than mdx mice, to represent a better model for Duchenne muscular dystrophy (DMD), we performed qualitative and quantitative analysis of skeletal muscle inflammation and fibrosis in mdx and mdx/utrn+/- littermates. Inflammation was significantly worse in mdx/utrn+/- quadriceps...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17889902
DOI: 10.1016/j.jns.2007.08.029
PMCID: PMC2696235

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Haploinsufficiency of utrophin gene worsens skeletal muscle inflammation and fibrosis in mdx mice.PMID 17889902Read ↗

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