Article
Ribosome protection prevents azithromycin-mediated quorum-sensing modulation and stationary-phase killing of Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy - 1 Dec 2007
Köhler Thilo, Dumas Jean-Luc, Van Delden Christian
Abstract excerpt
In Pseudomonas aeruginosa, azithromycin has been shown to reduce virulence factor production, to retard biofilm formation, and to exhibit bactericidal effects on stationary-phase cells. In this study we analyzed whether these azithromycin-mediated effects require interaction with the ribosome. We...
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