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Article

Interleukin-6 gene variants and the risk of sepsis development in children.

Human immunology - 1 Sept 2007

Michalek Jaroslav, Svetlikova Petra, Fedora Michal, Klimovic Michal, Klapacova Lenka, Bartosova Drahomira, Hrstkova Hana, Hubacek Jaroslav A

Abstract excerpt

A proinflammatory cytokine interleukin-6 (IL-6) plays an important role in the development, pathogenesis and outcome of SIRS, sepsis and septic shock. We have evaluated the role of the IL-6 gene polymorphisms in pediatric patients. A total of 421 consecutive pediatric patients admitted to the pediatric intensive care unit with fever, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17869650
DOI: 10.1016/j.humimm.2007.06.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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