Article
Defective synaptic transmission causes disease signs in a mouse model of juvenile neuronal ceroid lipofuscinosis
14 Nov 2017
Abstract excerpt
Juvenile neuronal ceroid lipofuscinosis (JNCL or Batten disease) caused by mutations in the CLN3 gene is the most prevalent inherited neurodegenerative disease in childhood resulting in widespread central nervous system dysfunction and premature death. The consequences of CLN3 mutation on the progression of the disease, on neuronal transmission, and on central nervous network dysfunction are poorly understood. We...
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