Article
Redetection of HBV lamivudine-resistant mutations in a patient under entecavir therapy, who had been treated sequentially with nucleos(t)ide analogues.
Journal of medical virology - 1 Nov 2007
Rodriguez-Frias Francisco, Jardi Rosendo, Schaper Melanie, Gimferrer Montserrat, Elefsiniotis Ioannis, Tabernero David, Esteban Rafael, Buti Maria
Abstract excerpt
Development of hepatitis B virus (HBV)-resistant strains following nucleos(t)ide analog treatment is a major medical concern. This report describes a case of an adult patient with chronic HBV infection, sequentially treated with the nucleos(t)ide analogues, lamivudine, adefovir, and entecavir. During monotherapy with lamivudine, the patient developed lamivudine-resistant variants, which were undetectable during...
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