Article
10 Swiss kindreds with multiple endocrine neoplasia type 1: assessment of screening methods.
Swiss medical weekly - 30 Jun 2001
Clerici T, Schmid C, Komminoth P, Lange J, Spinas G A, Brändle M
Abstract excerpt
PRINCIPLES: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disease characterised by the combined occurrence of tumours of the parathyroid glands, the enteropancreatic neuroendocrine system and the anterior pituitary gland. The genetic defect has been mapped to the long arm of chromosome 11q13, and the MEN1-gene was recently identified by positional cloning. Genetic screening for MEN1 germline...
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