Article
Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis.
PLoS biology - 1 Sept 2007
Söderhäll Cilla, Marenholz Ingo, Kerscher Tamara, Rüschendorf Franz, Esparza-Gordillo Jorge, Worm Margitta, Gruber Christoph, Mayr Gabriele, Albrecht Mario, Rohde Klaus, Schulz Herbert, Wahn Ulrich, Hubner Norbert, Lee Young-Ae
Abstract excerpt
Atopic dermatitis (AD) is a common chronic inflammatory skin disorder and a major manifestation of allergic disease. AD typically presents in early childhood often preceding the onset of an allergic airway disease, such as asthma or hay fever. We previously mapped a susceptibility locus for AD on Chromosome 3q21. To identify the underlying disease gene, we used a dense map of microsatellite markers and single...
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