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Accumulation of Glucosylceramide in Murine Testis, Caused by Inhibition of β-Glucosidase 2

11 Sept 2007

Abstract excerpt

One of the hallmarks of male germ cell development is the formation of a specialized secretory organelle, the acrosome. This process can be pharmacologically disturbed in C57BL/6 mice, and thus infertility can be induced, by small molecular sugar-like compounds (alkylated imino sugars). Here the biochemical basis of this effect has been investigated. Our findings suggest that in vivo alkylated imino sugars...

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PMID: 17848577
DOI: 10.1074/jbc.m702387200

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