Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine.

EMBO reports - 1 Oct 2007

Muncan Vanesa, Faro Ana, Haramis Anna-Pavlina G, Hurlstone Adam F L, Wienholds Erno, van Es Johan, Korving Jeroen, Begthel Harry, Zivkovic Danica, Clevers Hans

Abstract excerpt

Previous studies have shown that Wnt signals, relayed through beta-catenin and T-cell factor 4 (Tcf4), are essential for the induction and maintenance of crypts in mice. We have now generated a tcf4 (tcf7l2) mutant zebrafish by reverse genetics. We first observe a phenotypic defect at 4 weeks post-fertilization (wpf), leading to death at about 6 wpf. The phenotype comprises a loss of proliferation at the base of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryo, Nonmammalian
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization

Share to Intestinal Mucosa

Share to Intestines

Share to Transcription Factor 4

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 17823612
DOI: 10.1038/sj.embor.7401071
PMCID: PMC2002560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine.PMID 17823612Read ↗

The intestinal epithelium tuft cells: specification and functionSemantic proximity Read ↗

Analysis of Thyroid Hormone Receptor α-Knockout Tadpoles Reveals That the Activation of Cell Cycle Program Is Involved in Thyroid Hormone-Induced Larval Epithelial Cell Death and Adult Intestinal Stem Cell Development During Xenopus tropicalis MetamorphosisSemantic proximity Read ↗

The gastrointestinal development ‘parts list’: transcript profiling of embryonic gut development in wildtype and <i>Ret</i> -deficient miceSemantic proximity Read ↗

Live and let die in the intestinal epithelium.Semantic proximity Read ↗

Developmental regulation of intestinal <i>best4</i> + cellsSemantic proximity Read ↗

Intestinal growth and differentiation in zebrafish.Semantic proximity Read ↗

Wnt/β-Catenin Is Essential for Intestinal Homeostasis and Maintenance of Intestinal Stem CellsSemantic proximity Read ↗

Thyroid Hormone Receptor Is Essential for Larval Epithelial Apoptosis and Adult Epithelial Stem Cell Development but Not Adult Intestinal Morphogenesis during Xenopus tropicalis MetamorphosisSemantic proximity Read ↗

Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuhn is perturbed by stimulation of Lef-1/beta-catenin signaling.Semantic proximity Read ↗

ELT-2 is the predominant transcription factor controlling differentiation and function of the C. elegans intestine, from embryo to adult.Semantic proximity Read ↗

The EGFR signaling pathway controls gut progenitor differentiation during planarian regeneration and homeostasis.Semantic proximity Read ↗

Growth, Development, and Intestinal Remodeling Occurs in the Absence of Thyroid Hormone Receptor α in Tadpoles of Xenopus tropicalis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.