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Article

Ligation of CD200R by CD200 is not required for normal murine myelopoiesis.

European journal of haematology - 1 Nov 2007

Rijkers Eva S K, de Ruiter Talitha, Buitenhuis Miranda, Veninga Henrike, Hoek Robert M, Meyaard Linde

Abstract excerpt

CD200R is an inhibitory receptor involved in the regulation of myeloid cells. It recruits Dok-1 and Dok-2, which are potent inhibitors of the Ras signalling pathway used by colony-stimulating factor (CSF) receptors. Dok-1/Dok-2 double knockout (DKO) mice develop leukaemia at 10-12 months of age. We investigated whether disturbed CD200R signalling could be responsible for this phenotype. Therefore, we studied...

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PMID: 17803680
DOI: 10.1111/j.1600-0609.2007.00920.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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