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Significance of HER2 Low-Level Copy Gain in Barrett's Cancer: Implications for Fluorescence <i>In situ</i> Hybridization Testing in Tissues

1 Sept 2007

Abstract excerpt

PURPOSE: HER2 may be a relevant biomarker in Barrett's cancer. We compared three HER2 laboratory methods, standard fluorescence in situ hybridization (FISH), image-based three-dimensional FISH in thick (16 microm) sections, and immunohistochemistry, to predict patient outcome. EXPERIMENTAL DESIGN: Tissue microarray sections from 124 Barrett's cancer patients were analyzed by standard FISH on thin (4 microm)...

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PMID: 17785566
DOI: 10.1158/1078-0432.ccr-07-0465

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