Article
Increased steroidogenic factor-1 dosage triggers adrenocortical cell proliferation and cancer.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 2007
Doghman Mabrouka, Karpova Tatiana, Rodrigues Giovanna Assis, Arhatte Malika, De Moura Juliana, Cavalli Luciane R, Virolle Virginie, Barbry Pascal, Zambetti Gerard P, Figueiredo Bonald C, Heckert Leslie L, Lalli Enzo
Abstract excerpt
Steroidogenic factor-1 (SF-1/Ad4BP; NR5A1), a nuclear receptor transcription factor, has a pivotal role in adrenal and gonadal development in humans and mice. A frequent feature of childhood adrenocortical tumors is SF-1 amplification and overexpression. Here we show that an increased SF-1 dosage can by itself augment human adrenocortical cell proliferation through concerted actions on the cell cycle and...
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