Article
Simple sequence repeats provide a substrate for phenotypic variation in the Neurospora crassa circadian clock.
PloS one - 29 Aug 2007
Michael Todd P, Park Sohyun, Kim Tae-Sung, Booth Jim, Byer Amanda, Sun Qi, Chory Joanne, Lee Kwangwon
Abstract excerpt
BACKGROUND: WHITE COLLAR-1 (WC-1) mediates interactions between the circadian clock and the environment by acting as both a core clock component and as a blue light photoreceptor in Neurospora crassa. Loss of the amino-terminal polyglutamine (NpolyQ) domain in WC-1 results in an arrhythmic circadian clock; this data is consistent with this simple sequence repeat (SSR) being essential for clock function....
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