Article
Effect of transporter modulation on the emergence of nelfinavir resistance in vitro.
Antiviral therapy - 1 Jan 2007
Chandler Becky, Detsika Maria, Owen Andrew, Evans Sorcha, Hartkoorn Ruben C, Cane Patricia A, Back David J, Khoo Saye H
Abstract excerpt
BACKGROUND: HIV drug resistance is of increasing concern and could result from inadequate drug potency, poor therapy adherence and the existence of pharmacological sanctuary sites for viral replication. One contributing factor to the generation of such sites could be drug efflux transporters, which have been shown capable of effluxing HIV protease inhibitors from cells. METHODS: In this 'proof-of-concept' study,...
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