Article
Allele-sharing of cytokine genes in familial inflammatory bowel disease.
Hepato-gastroenterology - 1 Jan 2000
van der Linde K, Boor P P C, Mejissen M A C, Sandkuijl L A, Houwing-Duistermaat J J, Kuipers E J, Wilson J H P, de Rooij F W M
Abstract excerpt
BACKGROUND/AIMS: The pathogenesis of inflammatory bowel disease is complex, multifactorial, and involves genetic predisposition. This predisposition is likely to include various chromosomal loci, but simple Mendelian inheritance cannot be excluded in a subset of families with inflammatory bowel disease. METHODOLOGY: We evaluated allele-sharing in 17 sib-pairs with inflammatory bowel disease as an approach to...
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