Article
Polymorphisms of CAK genes and risk for lung cancer: a case-control study in Chinese population.
Lung cancer (Amsterdam, Netherlands) - 1 Nov 2007
Li Yuanchun, Jin Guangfu, Wang Haifeng, Liu Hongliang, Qian Ji, Gu Shaohua, Ma Hongxia, Miao Ruifeng, Hu Zhibin, Sun Weiwei, Wang Yi, Jin Li, Wei Qingyi, Shen Hongbing, Huang Wei, Lu Daru
Abstract excerpt
The incidence of lung cancer has been increasing over recent decades. Previous studies show that polymorphisms of the genes involved in carcinogen-detoxication, DNA repair and cell cycle control compose of the risk factors for lung cancer. Recent observations reveal that the components of CAK: Cdk7, MAT1 and cyclin H, may play important roles in cell cycle control, transcriptional control, and DNA repairing...
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