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Article

Susceptibility of germ-free pigs to challenge with protease mutants of Salmonella enterica serovar Typhimurium.

Immunobiology - 1 Jan 2007

Splichal Igor, Rychlik Ivan, Gregorova Daniela, Sebkova Alena, Trebichavsky Ilja, Splichalova Alla, Muneta Yoshihiro, Mori Yasuyuki

Abstract excerpt

Salmonella protease mutants, clpP and especially htrA, are candidate live oral vaccines in humans. A functional and mature immune system is, however, required to cope with them in mice. Here, we test the cytokine response of highly susceptible germ-free pigs to infection with Salmonella Typhimurium clpP and htrA mutants. Cytokine levels (IL-4, IL-10, IL-18 and IFN-gamma) were measured by ELISA in plasma and...

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Source

Identifiers

PMID: 17678715
DOI: 10.1016/j.imbio.2007.05.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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