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Synthetic multi‐epitope peptides identified <i>in silico</i> induce protective immunity against multiple influenza serotypes

2 Aug 2007

Abstract excerpt

Influenza causes yearly epidemics of mild disease and, occasionally, pandemics with millions of fatalities. Currently, no vaccine is effective against all influenza strains. Analysis of influenza sequences from animal and human isolates using CLUSTALW and a novel proprietary epitope prediction algorithm identified six conserved T cell-reactive regions in several proteins. Immunisation of transgenic mice with a...

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PMID: 17668898
DOI: 10.1002/eji.200737254

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