Article
DQA1*03011 allele: protective or an adverse effect on the development of sarcoidosis; preliminary study.
Respiratory medicine - 1 Oct 2007
Dubaniewicz Anna, Dubaniewicz Andrzej, Dubaniewicz Ada, Moszkowska Grazyna
Abstract excerpt
BACKGROUND: Sarcoidosis (SA) is a multisystem granulomatous disorder of unknown etiology. It seems likely that in genetically different predisposed hosts, the same antigen(s) may cause the development of sarcoid Th1 response. The interaction of the T-cell receptor with the human leukocyte antigen-DQA1*03011 peptide-complex can affect T lymphocytes activation in a dose-response manner. OBJECTIVES/METHODS: To test...
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