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Article

Destabilization of human glycine N-methyltransferase by H176N mutation.

Protein science : a publication of the Protein Society - 1 Sept 2007

Luka Zigmund, Pakhomova Svetlana, Luka Yury, Newcomer Marcia E, Wagner Conrad

Abstract excerpt

In the presence of moderate (2-4 M) urea concentrations the tetrameric enzyme, glycine N-methyltransferase (GNMT), dissociates into compact monomers. Higher concentrations of urea (7-8 M) promote complete denaturation of the enzyme. We report here that the H176N mutation in this enzyme, found in...

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Source

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Identifiers

PMID: 17660255
DOI: 10.1110/ps.072921507
PMCID: PMC2206963

Genes

GNMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17660255-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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