Synergistic action of vitamin E and vitamin C in vivo using a new mutant of Wistar-strain rats, ODS, unable to synthesize vitamin C.

doi:10.3177/jnsv.37.359

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Article

Synergistic action of vitamin E and vitamin C in vivo using a new mutant of Wistar-strain rats, ODS, unable to synthesize vitamin C.

Journal of nutritional science and vitaminology - 1 Aug 1991

Igarashi O, Yonekawa Y, Fujiyama-Fujihara Y

Abstract excerpt

It is well known that vitamins E and C exhibit synergistic action in in vitro systems, but with regard to in vivo systems, much of the available data are confusing. To elucidate this problem we used a new mutant of Wistar-strain rats that cannot synthesize vitamin C, namely, ODS rats. Two experim...

Topics

Animals
Ascorbic Acid
Body Weight
Diet
Drug Synergism
Erythrocytes
Male
Mutation
Rats
Rats, Inbred Strains
Rats, Mutant Strains
Tissue Distribution
Vitamin E
Vitamin E Deficiency

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