Article
Alpha-1-antitrypsin (AAT) anomalies are associated with lung disease due to rapidly growing mycobacteria and AAT inhibits Mycobacterium abscessus infection of macrophages.
Scandinavian journal of infectious diseases - 1 Jan 2007
Chan Edward D, Kaminska Aleksandra M, Gill Wendy, Chmura Kathryn, Feldman Nicole E, Bai Xiyuan, Floyd Corinne M, Fulton Kayte E, Huitt Gwen A, Strand Matthew J, Iseman Michael D, Shapiro Leland
Abstract excerpt
Rapidly growing mycobacteria (RGM) are ubiquitous in the environment but cause lung disease in only a fraction of exposed individuals. This variable susceptibility to disease implies vulnerability to RGM infection due to weakness in host defense. Since most persons who contract RGM lung disease have no known host defense defect, it is likely that uncharacterized host deficiencies exist that predispose to RGM...
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