Article
Pulmonary Nontuberculous Mycobacterial Infection. A Multisystem, Multigenic Disease.
American journal of respiratory and critical care medicine - 1 Sept 2015
Szymanski Eva P, Leung Janice M, Fowler Cedar J, Haney Carissa, Hsu Amy P, Chen Fei, Duggal Priya, Oler Andrew J, McCormack Ryan, Podack Eckhard, Drummond Rebecca A, Lionakis Michail S, Browne Sarah K, Prevots D Rebecca, Knowles Michael, Cutting Gary, Liu Xinyue, Devine Scott E, Fraser Claire M, Tettelin Hervé, Olivier Kenneth N, Holland Steven M
Abstract excerpt
RATIONALE: The clinical features of patients infected with pulmonary nontuberculous mycobacteria (PNTM) are well described, but the genetic components of infection susceptibility are not. OBJECTIVES: To examine genetic variants in patients with PNTM, their unaffected family members, and a control group. METHODS: Whole-exome sequencing was done on 69 white patients with PNTM and 18 of their white unaffected family...
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