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[Molecular mechanisms of antithrombin deficiency caused by T98I and A404T mutation].

Zhonghua yi xue za zhi - 10 Apr 2007

Zhou Rong-fu, Dai Jing, Fu Qi-hua, Wang Wen-bin, Xie Shuang, Ding Qiu-lan, Wang Xue-feng, Wang Hong-li

Abstract excerpt

OBJECTIVE: To study the molecular mechanisms of antithrombin (AT) deficiency caused by AT gene mutations T98I and A404T. METHODS: Wild-type and mutant AT cDNA expression plasmids (ATwt, AT T98I and AT A404T) were constructed and transfected into the monkey fibroblast of the line COS-7 or Chinese hamster ovary (CHO) cells. NH4Cl. ALLN and brefeldin A were added. ELISA was used to detect the AT: Ag. Pulse-chase...

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PMID: 17650426

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