Article
Candidate gene mutation analysis in bilateral adrenal pheochromocytoma and sympathetic paraganglioma.
Endocrine-related cancer - 1 Jun 2007
Korpershoek Esther, Petri Bart-Jeroen, van Nederveen Francien H, Dinjens Winand N M, Verhofstad Albert A, de Herder Wouter W, Schmid Sonja, Perren Aurel, Komminoth Paul, de Krijger Ronald R
Abstract excerpt
Pheochromocytomas (PCCs) are rare tumors that arise from chromaffin tissue in the adrenal medulla, but can also occur in the abdomen outside the adrenals and are then called sympathetic paragangliomas (sPGLs). According to the literature, between 15 and 25% of apparently sporadic adrenal PCC and sPGL are caused by germline mutations in RET, von Hippel-Lindau disease (VHL), succinate dehydrogenase subunit B...
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