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Article

An Epigenetically Derived Monoclonal Origin for Recurrent Respiratory Papillomatosis

1 Jul 2007

Abstract excerpt

OBJECTIVE: To investigate the contribution of promoter methylation-mediated epigenetic events in recurrent respiratory papillomatosis tumorigenesis. DESIGN: Archival tissue DNA, extracted from microdissected papilloma lesions, was interrogated for methylation status by means of the novel, multigene methylation-specific multiplex ligation-dependent probe amplification assay. SUBJECTS: Fifteen subjects with...

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PMID: 17638782
DOI: 10.1001/archotol.133.7.684

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