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Article

Three-dimensional modeling of glucose-6-phosphate dehydrogenase-deficient variants from German ancestry.

PloS one - 18 Jul 2007

Kiani Farooq, Schwarzl Sonja, Fischer Stefan, Efferth Thomas

Abstract excerpt

BACKGROUND: Loss of function of dimeric glucose-6-phosphate dehydrogenase (G6PD) represents the most common inborn error of metabolism throughout the world affecting an estimated 400 million people. In Germany, this enzymopathy is very rare. METHODOLOGY/PRINCIPAL FINDINGS: On the basis of G6PD crystal structures, we have analyzed six G6PD variants of German ancestry by three-dimensional modeling. All mutations...

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Identifiers

PMID: 17637841
DOI: 10.1371/journal.pone.0000625
PMCID: PMC1913203

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