Activation of targeted necrosis by a p53 peptide: a novel death pathway that circumvents apoptotic resistance.

Abstract excerpt

Cancer cells escape apoptosis by intrinsic or acquired mechanisms of drug resistance. An alternative strategy to circumvent resistance to apoptosis could be through redirection into other death pathways, such as necrosis. However, necrosis is a nonspecific, nontargeted process resulting in cell l...

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