Article
Amyloid imaging in distinguishing atypical prion disease from Alzheimer disease.
Neurology - 17 Jul 2007
Boxer A L, Rabinovici G D, Kepe V, Goldman J, Furst A J, Huang S-C, Baker S L, O'neil J P, Chui H, Geschwind M D, Small G W, Barrio J R, Jagust W, Miller B L
Abstract excerpt
OBJECTIVE: To compare the in vivo uptake of two amyloid-binding PET agents, PIB and FDDNP, in human subjects with a prion protein (PrP) gene (PRNP) mutation that produces a clinical syndrome similar to Alzheimer disease (AD). BACKGROUND: Amyloid imaging with specific PET ligands offers great promise for early detection and differential diagnosis of AD. Genetic forms of prion disease can present with clinical...
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