Article
ZEB1 and c-Jun levels contribute to the establishment of highly lytic Epstein-Barr virus infection in gastric AGS cells.
Journal of virology - 1 Sept 2007
Feng Wen-hai, Kraus Richard J, Dickerson Sarah J, Lim Hui Jun, Jones Richard J, Yu Xianming, Mertz Janet E, Kenney Shannon C
Abstract excerpt
The induction of lytic infection has been proposed as a therapeutic strategy for treating Epstein-Barr virus (EBV)-positive malignancies. To succeed, efficient methods are needed for activating the EBV immediate-early (IE) promoters, Zp and Rp. Here we compared factors which regulate Zp and Rp in AGS gastric carcinoma cells that support a remarkably high level of persistently lytic EBV infection with HeLa...
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